It will probably send your map to the grave, I suggest you set aside a whole day and work your way though your map putting all your brushes to the biggest grid size you can get away with, if it is a really small brush in all three dimentions then you probably want to func_detail it.
You always want to have the grid in 16 32 or 8 if you can, untill of course you need to put detailed brushes in that are smaller. Again, you should always be very carefull how you place brushes, make sure they line up to each other and the grid when you place them so that you don't have to worry about it later
Apparently using a smaller grid (eg 1, 2, 4) makes the compiling process harder and may or may not result in leaks. (correct me if I'm wrong)
Plus if you have things on a larger grid, you won't have to zoom in as much in Hammer...
edit: oh! And yes, you get smaller/bigger grid with [ & ].